Clone:
REAL1211
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
TP53-binding protein 1, TP53BP1, tumor protein p53 binding protein 1, p53-binding protein 1, p53BP1

Specifications for 53BP1 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1211 is an antibody fragment derived from the full 53BP1 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL1211 recognizes the human 53BP1 (tumor protein p53 binding protein 1), a Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. It promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

TP53-binding protein 1, TP53BP1, tumor protein p53 binding protein 1, p53-binding protein 1, p53BP1

Detailed product information

Technical specifications

CloneREAL1211
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Antigen53BP1
Alternative names of antigenTP53-binding protein 1, TP53BP1, tumor protein p53 binding protein 1, p53-binding protein 1, p53BP1
Distribution of antigenubiquitous

Resources for 53BP1 Antibody, anti-human, REAdye_lease™

Certificates

Please follow this
link
to search for Certificates of Analysis (CoA) by lot number.

References for 53BP1 Antibody, anti-human, REAdye_lease™

Publications

  1. Lottersberger, F. et al. (2013) Role of 53BP1 oligomerization in regulating double-strand break repair. Proc. Natl. Acad. Sci. U.S.A. 110(6): 2146-2151
  2. Callen, E. et al. (2013) 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell 153(6): 1266-1280
  3. Noordermeer, S. M. et al. (2018) The shieldin complex mediates 53BP1-dependent DNA repair. Nature 560(7716): 117-121

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