Clone:
REAL642
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IF, IHC
Alternative names:
MRP14, CFAG, CAGB, MRP-14, p14, S100 calcium-binding protein A9, Migration inhibitory factor-related protein 14, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit, Calgranulin-B

Specifications for S100A9 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL642 is an antibody fragment derived from the full S100A9 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL642 recognizes the human S100A9 calcium- and zinc-binding protein, a S100 family member, which is also known as MRP14 (migration inhibitory factor-related protein 14) or calgranulin B. S100A9 is expressed in a wide range of cells but it is predominantly expressed in myeloid cells. S100A9 plays a crucial role in the regulation of inflammatory processes and immune response. S100A8 and S100A9 form the heterodimer calprotectin, that has proinflammatory, antimicrobial, apoptosis-inducing activities and different intracellular functions, for example facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the NADPH-oxidase.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

MRP14, CFAG, CAGB, MRP-14, p14, S100 calcium-binding protein A9, Migration inhibitory factor-related protein 14, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit, Calgranulin-B

Detailed product information

Technical specifications

CloneREAL642
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenS100A9
Alternative names of antigenMRP14, CFAG, CAGB, MRP-14, p14, S100 calcium-binding protein A9, Migration inhibitory factor-related protein 14, Leukocyte L1 complex heavy chain, Calprotectin L1H subunit, Calgranulin-B
Distribution of antigenmonocytes, tumor cells, eosinophils, neutrophils

References for S100A9 Antibody, anti-human, REAdye_lease™

Publications

  1. Ryckman, C. et al. (2003) Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. J. Immunol. 170(6): 3233-3242
  2. Li, C. et al. (2009) A novel p53 target gene, S100A9, induces p53-dependent cellular apoptosis and mediates the p53 apoptosis pathway. Biochem. J. 422(2): 363-372
  3. Rammes, A. et al. (1997) Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J. Biol. Chem. 272(14): 9496-9502

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