Clone:
REAL658
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
BCC7, LFS1, P53, TP53

Specifications for p53 Antibody, anti-human, REAdye_lease™

Overview

Clone REAL658 is an antibody fragment derived from the full p53 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REAL658 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

BCC7, LFS1, P53, TP53

Detailed product information

Technical specifications

CloneREAL658
Clonalitymonoclonal
Isotype controlControl Antibody
Hosthuman cell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
Antigenp53
Alternative names of antigenBCC7, LFS1, P53, TP53
Distribution of antigenubiquitous, tumor cells, tumor, ovarian cancer
RRIDAB_2905358

Resources for p53 Antibody, anti-human, REAdye_lease™

Certificates

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References for p53 Antibody, anti-human, REAdye_lease™

Publications

  1. Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4(5): 1251-1255
  2. Lamb, P. et al. (1986) Characterization of the human p53 gene. Mol. Cell. Biol. 6(5): 1379-1385
  3. Stiewe, T. (2007) The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7(3): 165-168
  4. Surget, S. et al. (2013) Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. Onco Targets Ther. 7: 57-68

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