REAlease® CD192 (CCR2) Complexes, human

REAlease
®
CD192 (CCR2) Complexes
, human

Clone: REAL488 | Dilution: 1:50
Clone REAL488 is an antibody fragment derived from the full CD192 (CCR2) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAlease Complex to bind markers with high avidity.
Clone REAL488 recognizes the CD192 antigen, a G protein linked seven transmembrane receptor which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). Two spliced variants of CD192 (CD192A and CD192B) are expressed on peripheral monocytes and basophils as a result of alternate splicing of a single gene and differ at the C-terminal end. CD192 and its main ligand CCL2 have been implicated in a wide range of immunobiological processes and neuropathologies, including recruitment of monocytes and regulation of bone marrow homeostasis, as well as multiple sclerosis, HIV-associated dementia, Alzheimer’s disease, and neuropathic pain.
The REAlease Kits consist of the respective fluorochrome-conjugated REAlease Complexes and the REAlease Support Kit for removal of the REAlease Complexes and optional relabeling with different fluorochrome-conjugated REAlease Complexes.

Alternative names

C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R

Technical specifications

  • Antigen: CD192 (CCR2)
  • Clone: REAL488
  • Isotype control: REAL Control
  • Alternative names of antigen: C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CCR-2, Monocyte chemoattractant protein 1 receptor, MCP-1-R, MCP-1R
  • Distribution of antigen: monocytes, basophils
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
Product options: 4
for 30
tests
(1)
CHF  145.00
for 100
tests
(1)
CHF  350.00
for 30
tests
(1)
CHF  145.00
for 100
tests
(1)
CHF  350.00