CD94 antibodies, mouse

CD94 antibodies, mouse

Clone: REA1186 | Dilution: 1:50
Clone REA1186 recognizes the murine CD94 antigen, an approximately 70 kDa single-pass type II transmembrane protein, which belongs to C-type lectin superfamily. CD94 associates covalently with NKG2 family members and forms disulfide bonded heterodimers. CD94-NKG2 receptors bind HLA-E, the nonclassical MHC class Ib molecule. Depending on the associated NKG2 member, CD94-NKG2 heterodimer transmits either activating or inhibitory signal. For e.g via immunoreceptor tyrosine based-inhibitory motifs (ITIMs) containing NKG2A, CD94-NKG2A heterodimers inhibit NK cell cytotoxicity. Besides NK cells, expression of CD94-NKG2 heterodimers is also shown on NK-T cells and a small percentage of CD8
+
cells in most mouse strains. DBA/2J mice do not express CD94.
Additional information: Clone REA1186 displays negligible binding to Fc receptors.

Alternative names

Killer cell lectin-like receptor subfamily D member 1 (KLRD1), KLRD1

Technical specifications

  • Antigen: CD94
  • Clone: REA1186
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Killer cell lectin-like receptor subfamily D member 1 (KLRD1), KLRD1
  • Entrez Gene ID: 11643
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: NK cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin
  • Selected references

    1. Vance, R. E. et al. (1997) Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells. Eur. J. Immunol. 27(12): 3236-3241
    2. Ho, E. L. et al. (1998) Murine Nkg2d and CD94 are clustered within the natural killer complex and are expressed independently in natural killer cells. Proc. Natl. Acad. Sci. U.S.A. 95(11): 6320-6325
Product options: 11
130-122-059

CD94-PE, mouse

30 µg in 200 µL (1)
CHF  85.00
130-122-052

CD94-PE, mouse

150 µg in 1 mL (1)
CHF  250.00
130-122-060

CD94-APC, mouse

30 µg in 200 µL (1)
CHF  85.00
30 µg in 200 µL (1)
CHF  110.00
150 µg in 1 mL (1)
CHF  325.00
30 µg in 200 µL (1)
CHF  110.00
150 µg in 1 mL (1)
CHF  325.00
30 µg in 200 µL (1)
CHF  160.00
150 µg in 1 mL (1)
CHF  460.00
30 µg in 200 µL (1)
CHF  45.00
150 µg in 1 mL (1)
CHF  130.00

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