CD93 antibodies, mouse

CD93 antibodies, mouse

Clone: REA298 | Dilution: 1:50
Clone REA298 recognizes the mouse CD93 antigen, C-type lectin like type I transmembrane protein also known as also known as AA4.1 antigen or C1QR1. CD93 is widely expressed on hematopoietic cells such as immature dendritic cells, monocytes and macrophages, and immature B lymphocytes but also on hematopoietic progenitors and stem cells in adult bone marrow, embryonic yolk sac, and fetal liver. It mediates the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens and plays a role in intercellular adhesion. CD93 is a marker for early multipotent hematopoietic precursor cells and plays a role in cell-cell interactions during hematopoietic and vascular development. It is also involved in other immunological processes such as enhancement of bacterial phagocytosis, clearance of apoptotic cells, or neutralisation of virus.
Additional information: Clone REA298 displays negligible binding to Fc receptors.

Alternative names

AA4.1, C1QR1, C1qRp, Ly68

Technical specifications

  • Antigen: CD93
  • Clone: REA298
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: AA4.1, C1QR1, C1qRp, Ly68
  • Entrez Gene ID: 17064
  • Molecular mass of antigen [kDa]: 67
  • Distribution of antigen: B cells, monocytes, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected references

    1. Norsworthy, P. J. et al. (2004)
      Murine CD93 (C1qRp) contributes to the removal of apoptotic cells
      in vivo
      but is not required for C1q-mediated enhancement of phagocytosis.
      J. Immunol. 172(6): 3406-3414
    2. Petrenko, O. et al. (1999) The molecular characterization of the fetal stem cell marker AA4. Immunity 10(6): 691-700
    3. Jacque, E. et al. (2015) BAFF activation of the ERK5 MAP kinase pathway regulates B cell survival. J. Exp. Med. 212: 883-892
    4. Kim, T. S. et al. (2000) Characterization of the murine homolog of C1qR(P): identical cellular expression pattern, chromosomal location and functional activity of the human and murine C1qR(P). Mol. Immunol. 37(7): 377-389
Product options: 1
30 µg in 200 µL (1)
CHF  116.00

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