CD86 antibodies, rat

CD86 antibodies, rat

Clone: 24F | Dilution: 1:50
Clone 24F recognizes the rat antigen CD86, also known as B7-2, which is a member of the B7 family of costimulatory molecules. In addition to CD80 (B7-1) , CD86 is a counter-receptor for the T cell surface molecules CD28 and CD152 (CTLA-4). It is expressed by germinal center B cells and weakly expressed on antigen presenting cells, such as macrophages and dendritic cells. Its expression is upregulated on B cells through a variety of surface stimuli including LPS. CD86 plays a critical role in the early events of T cell activation and costimulation of naive T cells as well as autoantibody and Tʜ2-mediated Ig production.

Alternative names

B7-2, B70

Technical specifications

  • Antigen: CD86
  • Clone: 24F
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: B7-2, B70
  • Entrez Gene ID: 56822
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: B cells, dendritic cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770
  • Selected references

    1. Bluestone, J. A. et al. (1995) New perspectives of CD28-B7-mediated T cell costimulation. Immunity 2(6): 555-559
    2. Maeda, K. et al. (1997) Characterization of rat CD80 and CD86 by molecular cloning and mAb. Int. Immunol. 9(7): 993-1000
    3. Damoiseaux, J. G. et al. (1998) Costimulatory molecules CD80 and CD86 in the rat; tissue distribution and expression by antigen-presenting cells. J. Leukoc. Biol. 64(6): 803-809
Product options: 1
30 µg in 200 µL (1)
CHF  116.00

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