CD85k (ILT3) antibodies, human

CD85k (ILT3) antibodies, human

Clone: REA141 | Dilution: 1:11
Clone REA141 recognizes CD85k, a member of regulatory immune receptor family, also known as leukocyte immunoglobulin-like receptor (LILRs/LIRs), immunoglobulin-like transcripts (ILTs), or CD85 family. CD85k is a type I membrane protein with two extracellular Ig-like domains, intracellular immunoreceptor tyrosine-based inhibitory motifs (ITIM) and is expressed on monocytes, dendritic cells, and macrophages. In addition, suppressor T cells induce the expression of CD85k on antigen presenting cells.
Additional information: Clone REA141 displays negligible binding to Fc receptors.

Alternative names

LILRB4, ILT3, LIR-5

Technical specifications

  • Antigen: CD85k (ILT3)
  • Clone: REA141
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LILRB4, ILT3, LIR-5
  • Entrez Gene ID: 11006
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: monocytes, dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Colonna, M. et al. (1997) A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J. Exp. Med. 186: 1809-1818
    2. Cheng, H. et al. (2011) Crystal structure of leukocyte Ig-like receptor LILRB4 (ILT3/LIR-5/CD85k): A myeloid inhibitory receptor involved in immune tolerance. J. Biol. Chem. 286: 18013-18025
    3. Sommer, A. and Fabri, M. (2015) Vitamin D regulates cytokine patterns secreted by dendritic cells to promote differentiation of IL-22-producing T cells. PLoS One 10(6): e0130395
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