CD84 antibodies, mouse

CD84 antibodies, mouse

Clone: REA212 | Dilution: 1:10
Clone REA212 recognizes murine CD84, a type I transmembrane glycoprotein belonging to the SLAM (CD150) family, a CD2 subset of the Ig superfamily of cell-surface receptors. Genes encoding for SLAM members are located on the syntenic region of mouse chromosome 1 and these receptors play vital role in regulation of innate and adaptive immune responses. CD84, like other SLAM receptors has an extracellular ectodomain formed by two Ig-like domains and a cytoplasmic domain with 2 copies of the ITSM (T-I/V-Y-x-x-V/I) motif, which is a docking site for SH2-binding phosphatases and the adaptor molecules SAP and EAT-2. CD84 serves as a self ligand and displays homophilic interaction via its N-terminal Ig domain. Expression of CD84 is found on a variety of cells including B, T, mast cell, platelets, monocytes, macrophages, granulocytes, dendritic cell and Hematopoietic stem cells (HSCs). CD84 has been implicated in regulation of functions such as T cell proliferation, FcεRI-mediated signalling in mast cells, and stability of platelets aggregates.
Additional information: Clone REA212 displays negligible binding to Fc receptors.

Alternative names

CDw84, SLAMF5, Ly9b, GR6

Technical specifications

  • Antigen: CD84
  • Clone: REA212
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CDw84, SLAMF5, Ly9b, GR6
  • Distribution of antigen: B cells, T cells, platelets, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Martin, M. et al. (2001) CD84 functions as a homophilic adhesion molecule and enhances IFN-γ secretion: adhesion is mediated by Ig-like domain 1. J. Immunol. 167: 3668-3676
    2. Yan, Q. et al. (2007) Structure of CD84 provides insight into SLAM family function. Proc. Natl. Acad. Sci. U.S.A. 104: 10583-10588
Product options: 4
130-103-117

CD84-PE, mouse

9 µg in 300 µL (1)
CHF  42.00
130-102-618

CD84-PE, mouse

30 µg in 1 mL (1)
CHF  85.00
130-103-116

CD84-APC, mouse

9 µg in 300 µL (1)
CHF  65.00
130-102-592

CD84-APC, mouse

30 µg in 1 mL (1)
CHF  85.00

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