CD79b antibodies, human

CD79b antibodies, human

Clone: REA120 | Dilution: 1:50
Clone REA120 detects the extracellular epitope of CD79b, the β chain of heterodimeric molecule CD79. CD79 is composed of an α chain (CD79a) and a β chain (CD79b) and is associated with surface immunoglobulins (Igs) to form the B cell receptor (BCR). CD79b is 37–39 kDa type I integral membrane protein and like CD79a contains an intracellular immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Patients with chronic lymphocytic leukemia (CLL) B cells lack a functional BCR which is often associated with mutations in CD79b coding region.
Additional information: Clone REA120 displays negligible binding to Fc receptors.

Alternative names

AGM6, B29, Igb

Technical specifications

  • Antigen: CD79b
  • Clone: REA120
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: AGM6, B29, Igb
  • Entrez Gene ID: 974
  • Molecular mass of antigen [kDa]: 23
  • Cross-reactivity:
    chimpanzee (
    Pan troglodytes
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC
  • Selected references

    1. Lin, J. and Justement, L. B. (1992) The MB-1/B29 heterodimer couples the B cell antigen receptor to multiple src family protein tyrosine kinases. J. Immunol. 149: 1548-1555
    2. Koyama, M. et al. (1997) CD79α/CD79β heterodimers are expressed on pro-B cell surfaces without associated μ heavy chain. Int. Immunol. 9: 1767-1772
    3. Gordon, M. S. et al. (2000) Aberrant B cell receptor signaling from B29 (Igβ, CD79b) gene mutations of chronic lymphocytic leukemia B cells. Proc. Natl. Acad. Sci. U.S.A. 97: 5504-5509
Product options: 2
for 30
CHF  137.00
for 100
CHF  331.00

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