CD59 antibodies, human

CD59 antibodies, human

Clone: REA496 | Dilution: 1:11
Clone REA496 recognizes the human CD59 antigen, a 20 kDa LY-6 like protein, which regulates the action of the complement membrane attack complex on homologous cells. This glycoprotein is widely distributed on the membranes of human erythrocytes and leukocytes. CD59, also known as protectin, was observed in vascular endothelia throughout the body, in extravascular tissues, and was also found in ductal epithelia of pancreatic, biliary and salivary systems, bronchi, and kidney collecting ducts. Furthermore, CD59 is expressed in the epidermis and in the syncytiotrophoblast of placenta.
Additional information: Clone REA496 displays negligible binding to Fc receptors.

Alternative names

MIC11, MSK21, Protectin, MAC-IP, MIRL, G344, HRF-20, HRF20, MACIF

Technical specifications

  • Antigen: CD59
  • Clone: REA496
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MIC11, MSK21, Protectin, MAC-IP, MIRL, G344, HRF-20, HRF20, MACIF
  • Entrez Gene ID: 966
  • Molecular mass of antigen [kDa]: 9
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    , baboon
  • Distribution of antigen: leukocytes, red blood cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, Biotin
  • Selected references

    1. Davies, A. et al. (1989) CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells. J. Exp. Med. 170(3): 637-654
    2. Philbrick, W. M. et al. (1990) The CD59 antigen is a structural homologue of murine Ly-6 antigens but lacks interferon inducibility. Eur. J. Immunol. 20(1): 87-92
    3. Meri, S. et al. (1991) Distribution of protectin (CD59), a complement membrane attack inhibitor, in normal human tissues. Lab. Invest. 65(5): 532-537
Product options: 4
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  100.00
for 100
tests
(1)
CHF  245.00