CD54 (ICAM-1) antibodies, human

CD54 (ICAM-1) antibodies, human

Clone: REA266 | Dilution: 1:11
Clone REA266 recognizes human CD54, a 85–110 kDa type I transmembrane glycoprotein, which also known as intercellular adhesion molecule 1 (ICAM-1). CD54 is continuously present in low concentrations in the membranes of monocytes/macrophages, lymphocytes, activated endothelial cells, granulocytes, and dendritic cells. Its expression is regulated by inflammatory cytokines and can be induced by interleukin 1 (IL-1) and tumor necrosis factor. CD54 is a ligand for LFA-1, a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via CD54/LFA-1 and then transmigrate into tissues. CD54 has been shown to interact with CD11a, EZR, and CD18. More recently, CD54 has been characterized as a site for the cellular entry of human rhinovirus.
Additional information: Clone REA266 displays negligible binding to Fc receptors.

Alternative names

ICAM-1, BB2, P3.58

Technical specifications

  • Antigen: CD54 (ICAM-1)
  • Clone: REA266
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ICAM-1, BB2, P3.58
  • Entrez Gene ID: 3383
  • Molecular mass of antigen [kDa]: 55
  • Distribution of antigen: monocytes, macrophages, dendritic cells, endothelial cells, lymphocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Simmons, D. et al. (1988) ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. Nature 331(6157): 624-627
    2. Greve, J. M. et al. (1989) The major human rhinovirus receptor is ICAM-1. Cell 56(5): 839-847
    3. Shimaoka, M. et al. (2003) Structures of the α L I domain and its complex with ICAM-1 reveal a shape-shifting pathway for integrin regulation. Cell 112(1): 99-111
    4. Vernot, J. P. et al. (2017)
      Phenotypic and functional alterations of hematopoietic stem and progenitor cells in an
      in vitro
      leukemia-induced microenvironment.
      Int J Mol Sci 18(2): E199
Product options: 6
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CHF  315.00
for 30
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CHF  100.00
for 100
tests
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CHF  245.00