CD39 antibodies, human

CD39 antibodies, human

Clone: MZ18-23C8 | Dilution: 1:11
The CD39 antibody specifically recognizes the membrane-bound human CD39 antigen, which is expressed on an effector/memory-like subset of FoxP3
+
regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, which is an ecto-5’-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells.
Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells.

Alternative names

Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80

Technical specifications

  • Antigen: CD39
  • Clone: MZ18-23C8
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Entpd1, ATPDase, NTPDase-1, SPG64, EC3.6.1.5, gp80
  • Entrez Gene ID: 953
  • Molecular mass of antigen [kDa]: 58
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: B cells, dendritic cells, endothelial cells, Langerhans cells, lymphocytes, macrophages, monocytes, NK cells, placenta, platelets, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, pure
  • Selected references

    1. Borsellino, G. et al. (2007)
      Expression of ectonucleotidase CD39 by FoxP3
      +
      reg cells: hydrolysis of extracellular ATP and immune suppression.
      Blood 110: 1225-1232
Product options: 12
130-099-383

CD39-FITC, human

for 30
tests
(1)
CHF  100.00
130-093-502

CD39-FITC, human

for 100
tests
(1)
CHF  245.00
130-100-459

CD39-APC, human

for 30
tests
(1)
CHF  120.00
130-093-504

CD39-APC, human

for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  305.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 100
tests
(1)
CHF  245.00
130-093-506

CD39 pure, human

100 µg in 1 mL
CHF  147.00

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