CD357 (GITR) antibodies, mouse

CD357 (GITR) antibodies, mouse

Clone: REA980 | Dilution: 1:50
Clone REA980 recognizes the mouse CD357 antigen, also known as glucocorticoid-induced TNF-receptor (GITR) or TNFRSF18. CD357 is a member of the TNF receptor superfamily. It is expressed at low levels on resting T lymphocytes and at high levels on CD4
+
CD25
+
regulatory T cells (Tregs). Activation of T cells upregulates CD357 expression. Interaction of CD357 (GTITR) with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production, as well as MAPKs and NF-κB activation. CD357 plays an important role in the function of CD4
+
CD25
+
Tregs.
Additional information: Clone REA980 displays negligible binding to Fc receptors.

Alternative names

GITR, TNFRSF18, AITR

Technical specifications

  • Antigen: CD357 (GITR)
  • Clone: REA980
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: GITR, TNFRSF18, AITR
  • Entrez Gene ID: 21936
  • Molecular mass of antigen [kDa]: 23
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, VioBright 515, Biotin
  • Selected references

    1. Nocentini, G. et al. (1997) A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 94: 6216-6221
    2. Ronchetti, S. et al. (2002) Role of GITR in activation response of T lymphocytes. Blood 100(1): 350-352
    3. Rochetti, S. et al. (2004) GITR, a member of the TNF receptor superfamily, is costimulatory to mouse T lymphocyte subpopulations. Eur. J. Immunol. 34(3): 613-622
Product options: 12
30 µg in 200 µL (1)
CHF  45.00
150 µg in 1 mL (1)
CHF  130.00
30 µg in 200 µL (1)
CHF  85.00
150 µg in 1 mL (1)
CHF  250.00
30 µg in 200 µL (1)
CHF  85.00
150 µg in 1 mL (1)
CHF  250.00
30 µg in 200 µL (1)
CHF  110.00
150 µg in 1 mL (1)
CHF  325.00
30 µg in 200 µL (1)
CHF  160.00
150 µg in 1 mL (1)
CHF  460.00
30 µg in 200 µL (1)
CHF  45.00
150 µg in 1 mL (1)
CHF  130.00

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