CD279 (PD1) antibodies, mouse

CD279 (PD1) antibodies, mouse

Clone: HA2-7B1 | Dilution: 1:10
CD279 (PD1) is a 55 kDa member of the Ig superfamily expressed mainly on activated T and B lymphocytes. Expression is induced on activated myeloid cells as well. CD279 (PD1) is thought to be involved in lymphocyte clonal selection and plays a key role in peripheral tolerance and autoimmune disease in mice. The ligands of CD279 (PD1), PD-L1 (B7-H1) and PD-L2 (B7-DC), belong to the B7 immunoglobulin superfamily. Clone HA2-7B1 has been used to block the binding of PD1 to its ligands.

Alternative names

PDCD1, Ly101, PD1, Pdc1

Technical specifications

  • Antigen: CD279 (PD1)
  • Clone: HA2-7B1
  • Isotype: rat IgG2b
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: PDCD1, Ly101, PD1, Pdc1
  • Entrez Gene ID: 18566
  • Molecular mass of antigen [kDa]: 29
  • Distribution of antigen: B cells, monocytes, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Hirano, F. et al. (2005) Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunitiy. Cancer Res. 65: 1089-1096
    2. Iwai, Y. et al. (2002) Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl. Acad. Sci. U.S.A. 99: 12293-12297
    3. Salama, A. D. et al. (2003) Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 198: 71-78
    4. Tsushima, F. et al. (2007) Interaction between B7-H1 and PD-1 determines initiation and reversal of T cell anergy. Blood 110: 180-185
Product options: 5
9 µg in 300 µL (1)
CHF  33.00
30 µg in 1 mL (1)
CHF  45.00
30 µg in 1 mL (1)
CHF  85.00
30 µg in 1 mL (1)
CHF  85.00
30 µg in 1 mL (1)
CHF  45.00

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