CD277 antibodies, human

CD277 antibodies, human

Clone: BT3.1 | Dilution: 1:11
Clone BT3.1 recognizes the human CD277 antigen, a single-pass type I membrane protein, which is also known as butyrophilin subfamily 3 member A1 (BTN3A1). CD277 belongs to the B7 family members and is expressed in various immune cells such as T cells, B cells, monocytes, NK cells, dendritic cells, a subset of stem cells, and endothelial cells. It is also consistently expressed in stromal and some tumor cells. CD277 triggering considerably enhances T cell receptor (TCR) induced cytokine production and cell proliferation. It mediates the response of T cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate.

Alternative names

BTN3A1, BTF5, BTN3.1, BTN3A2, BT3.2, BTF4, BTN3.2, BT3.1

Technical specifications

  • Antigen: CD277
  • Clone: BT3.1
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: BTN3A1, BTF5, BTN3.1, BTN3A2, BT3.2, BTF4, BTN3.2, BT3.1
  • Entrez Gene ID: 11119
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: B cells, cancer stem cells, dendritic cells, endothelial cells, monocytes, stromal cells, T cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, Biotin
  • Selected references

    1. Tazi-Ahnini, R. et al. (1997) Cloning, localization, and structure of new members of the butyrophilin gene family in the juxta-telomeric region of the major histocompatibility complex. Immunogenetics 47(1): 55-63
    2. Messal, N. et al. (2011) Differential role for CD277 as a co-regulator of the immune signal in T and NK cells. Eur. J. Immunol. 41(12): 3443-3454
Product options: 2
for 30
CHF  105.00
for 100
CHF  257.00

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