Clone HK5.3 recognises murine CD275, which is also known as B7-H2 and ICOSL. CD275 is a type I membrane protein and belongs to the Ig superfamily, B7 family of costimulatory molecules. Expression of CD275 is found on antigen presenting cells such as B cells, dendritic cells, and monocytes. CD275 costimulates T cells upon binding to ICOS, which is expressed on activated T cells. In mouse, CD275 binds only ICOS, whereas in humans it can interact with other T cell costimulatory molecules, CD28 and CTLA-4. To appropriately regulate the activation of immune response, the ICOS-CD275 interaction can also lead to downregulation of CD275 expression which allows prevention of hyperreaction of T cells.
The mouse CD275 pure – functional grade antibody is suited for functional assays, for example, in vitro
and in vivo
blocking of ligand binding to B7RP-1 on mouse antigen presenting cells.
ICOSL, B7-H2, B7RP-1, GL50, LICOS, ICOS-Lg, Ly115l, B7h, GI50, GL50-B