CD273 (PD-L2) antibodies, human

CD273 (PD-L2) antibodies, human

Clone: MIH18 | Dilution: 1:50
Clone MIH18 recognizes human CD273, also known as B7-DC and PD-L2. CD273 with an approximate molecular weight of 25 kDa is a type I transmembrane protein, belonging to the B7 family of protein ligands and to the Ig superfamily. CD273 is mainly expressed on dendritic cells (DCs) and activated macrophages. It has been shown to interact with programmed-death-receptor 1 (PD-1). Both a stimulatory and inhibitory role of CD273, in T cell activation has been proposed.

Alternative names

PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Technical specifications

  • Antigen: CD273 (PD-L2)
  • Clone: MIH18
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: PDCD1LG2, B7-DC, Btdc, CD273, PD-L2, PDCD1L2, PDL2
  • Entrez Gene ID: 80380
  • Molecular mass of antigen [kDa]: 29
  • Distribution of antigen: dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770
  • Selected references

    1. Tseng, S. Y. et al. (2001)
      B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells.
      J. Exp. Med. 193: 839-846
    2. Pfistershammer, K. et al. (2006) No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation. Eur. J. Immunol. 36(5): 1104-1113
    3. Greenwald, R. J. et al. (2005) The B7 family revisited. Annu. Rev. Immunol. 23: 515-548
Product options: 2
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00

Related products

4 products available