CD233 antibodies, human

CD233 antibodies, human

Clone: REA368 | Dilution: 1:10
Clone REA368 recognizes the human CD233 antigen, a multi-pass membrane protein also known as anion exchange protein 1 (AE1) or solute carrier family 4 member 1 (SLC4A1). CD233 is a phylogenetically preserved transport protein responsible for mediating the electroneutral anion exchange of chloride for bicarbonate across a plasma membrane. It is the major integral membrane glycoprotein of the erythrocyte membrane and is required for the normal flexibility and stability of the erythrocyte membrane as well as for the normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. CD233 mediates the chloride-bicarbonate exchange in the kidney, and is required for the normal acidification of the urine.
Additional information: Clone REA368 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: CD233
  • Clone: REA368
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: SLC4A1, AE1
  • Entrez Gene ID: 652
  • Molecular mass of antigen [kDa]: 102
  • Distribution of antigen: other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, FITC
  • Selected references

    1. Rungaldier, S. et al. (2013) Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains. Biochim. Biophys. Acta 1828(3): 956-966
    2. Barneaud-Rocca, D. et al. (2013) Structural model of the anion exchanger 1 (SLC4A1) and identification of transmembrane segments forming the transport site. J. Biol. Chem. 288(37): 26372-26384
    3. Al-Samir, S. et al. (2013) Activity and distribution of intracellular carbonic anhydrase II and their effects on the transport activity of anion exchanger AE1/SLC4A1. J. Physiol. 591(20): 4963-4982
Product options: 2
for 30
CHF  110.00
for 100
CHF  263.00

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