CD204 antibodies, human

CD204 antibodies, human

Clone: REA460 | Dilution: 1:50
Clone REA460 recognizes the human CD204 antigen, a single-pass type II membrane protein which is also known as macrophage scavenger receptor type I (MSR1) or scavenger receptor class A (SR-A). CD204 is one of the major scavenger receptors expressed on human macrophages and dendritic cells. It plays roles in lipid metabolism, atherogenesis, and a number of metabolic processes. Recent evidence also points to important roles for CD204 in inflammation, innate immunity, host defense, sepsis, and ischemic injury. CD204 inhibits macrophage activation by scavenging ligands of toll-like receptor 4 and suppresses inflammatory cytokine production. Immunohistochemical studies in gliomas, pancreatic cancer, kidney cancer, esophageal cancer, and lung cancer have shown that CD204 expression in tumor tissues is closely restricted to tumor-associated macrophages and that high expression of CD204 is associated with a high malignant potential of tumor cells.
Additional information: Clone REA460 displays negligible binding to Fc receptors.

Alternative names

MSR1, SCARA1, SR-A, phSR1, phSR2, SR-AI

Technical specifications

  • Antigen: CD204
  • Clone: REA460
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: MSR1, SCARA1, SR-A, phSR1, phSR2, SR-AI
  • Entrez Gene ID: 4481
  • Molecular mass of antigen [kDa]: 50
  • Distribution of antigen: macrophages, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC
  • Selected references

    1. Matsumoto, A. et al. (1990) Human macrophage scavenger receptors: primary structure, expression, and localization in atherosclerotic lesions. Proc. Natl. Acad. Sci. U.S.A. 87(23): 9133-9137
    2. Yi, H. et al. (2011) Targeting the immunoregulator SRA/CD204 potentiates specific dendritic cell vaccine-induced T-cell response and antitumor immunity. Cancer Res. 71(21): 6611-6620
    3. Saito, Y. et al. (2014) Role of CD204-positive tumor-associated macrophages in adult T-cell leukemia/lymphoma. J. Clin. Hematop. 54(1): 59-65
Product options: 2
for 30
CHF  137.00
for 100
CHF  331.00

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