CD193 (CCR3) antibodies, mouse

CD193 (CCR3) antibodies, mouse

Clone: REA122 | Dilution: 1:10
Clone REA122 recognizes CD193, also known as CCR3 . CD193 is a seven transmembrane, β chemokine receptor belonging to the family of G protein-coupled receptors. Though CD193 is known primarily for its expression on eosinophils, its abundant expression is also found on mast cells, basophils, platelets and mononuclear phagocytes. CD193 binds to chemokines such as eotaxin-1, -2, -3, monocyte chemotactic proteins-2, -3, -4, RANTES and MIP-1α. An increased expression of these chemokines stimulate cells bearing CCR3 and promote their migration and recruitment at the site of inflammation, such as airway and conjuctiva. Thus, an important role of CD193 has been implicated in various allergic diseases such as bronchial asthma and allergic conjuctivitis.
Additional Information: Clone REA122 displays negligible binding to Fc receptors.

Alternative names

CCR3, CC-CKR3, CKR3, Cmkbr1l2, CMKBR3

Technical specifications

  • Antigen: CD193 (CCR3)
  • Clone: REA122
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR3, CC-CKR3, CKR3, Cmkbr1l2, CMKBR3
  • Entrez Gene ID: 12771
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: eosinophils, mast cells, basophils, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, PerCP-Vio700
  • Selected references

    1. Tachimoto, H. et al. (2000)
      CCR3-active chemokines promote rapid detachment of eosinophils from VCAM-1
      in vitro
      .
      J. Immunol. 165: 2748-2754.
    2. Moon, K. et al. (2007)
      Allergen-induced CD11b
      +
      CD11cint CCR3
      +
      macrophages in the lung promote eosinophilic airway inflammation in a mouse asthma model.
      Int. Immunol. 19: 1371-1381
    3. Fukuda, K. et al. (2012) The murine CCR3 receptor regulates both eosinophilia and hyperresponsiveness in IgE-mediated allergic conjunctivitis. Br. J. Ophthalmol. 96: 1132-1136
Product options: 8
9 µg in 300 µL (1)
CHF  42.00
30 µg in 1 mL (1)
CHF  85.00
9 µg in 300 µL (1)
CHF  65.00
30 µg in 1 mL (1)
CHF  85.00
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00

Related products

2 products available