CD166 antibodies, mouse

CD166 antibodies, mouse

Clone: REA370 | Dilution: 1:10
Clone REA370 recognizes the mouse CD166 antigen, a Single-pass type I membrane protein also known as Activated leukocyte cell adhesion molecule (ALCAM). CD166 is a member of the immunoglobulin gene superfamily which is expressed by activated leukocytes and thymic epithelial cells and is a ligand for the lymphocyte antigen CD6. It is also expressed at high levels in the brain and lung, at lower levels in the liver and the kidney, and on a number of cell lines. CD166 expression is pathologically correlated with aggressive disease in a variety of cancers including melanoma, prostate, breast, ovarian, esophageal, and bladder cancers. It is also a universal functional marker of murine and human hematopoietic stem cells (HSC) and osteoblasts within the hematopoietic niche and it is involved in modulating HSC-niche interactions and HSC fate.
Additional information: Clone REA370 displays negligible binding to Fc receptors.

Alternative names

ALCAM, BEN, DM-GRASP, MuSC, SC1

Technical specifications

  • Antigen: CD166
  • Clone: REA370
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: ALCAM, BEN, DM-GRASP, MuSC, SC1
  • Entrez Gene ID: 11658
  • Molecular mass of antigen [kDa]: 62
  • Distribution of antigen: leukocytes, thymic epithelial cells, brain, lung, liver, kidney, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Bowen, M. A. et al. (1997) Characterization of mouse ALCAM (CD166): the CD6-binding domain is conserved in different homologs and mediates cross-species binding. Eur. J. Immunol. 27(6): 1469-1478
    2. Chitteti, B. R. et al. (2013) CD166 and regulation of hematopoiesis. Curr. Opin. Hematol. 20(4): 273-280
    3. Levin, T. G. et al. (2010) Characterization of the intestinal cancer stem cell marker CD166 in the human and mouse gastrointestinal tract. Gastroenterology 139(6): 2072-2082
Product options: 6
130-105-489

CD166-PE, mouse

9 µg in 300 µL (1)
CHF  42.00
130-105-446

CD166-PE, mouse

30 µg in 1 mL (1)
CHF  85.00
130-105-487

CD166-APC, mouse

9 µg in 300 µL (1)
CHF  65.00
130-105-444

CD166-APC, mouse

30 µg in 1 mL (1)
CHF  85.00
9 µg in 300 µL (1)
CHF  28.00
30 µg in 1 mL (1)
CHF  45.00

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