CD137L (4-1BBL) antibodies, mouse

CD137L (4-1BBL) antibodies, mouse

Clone: REA962 | Dilution: 1:50
Clone REA962 recognizes the mouse CD137L antigen, a single-pass type II membrane protein also known as 4-1BB ligand (4-1BBL) or tumor necrosis factor ligand superfamily member 9 (Tnfsf9). CD137L is expressed on activated antigen-presenting cells and plays an essential role in regulating adaptive immune responses. Its receptor, 4-1BB is an inducible co-stimulatory member of the tumor necrosis factor receptor family expressed on activated CD4 and CD8 T cells. 4-1BB can enhance both the proliferation and the survival of murine CD4 and CD8 T cells. Recent evidence in mouse models suggests that 4-1BB/CD137L interaction plays an important role in the memory CD8 T cell response to viruses.
Additional information: Clone REA962 displays negligible binding to Fc receptors.

Alternative names

4-1BB ligand, 4-1BBL, TNFSF9

Technical specifications

  • Antigen: CD137L (4-1BBL)
  • Clone: REA962
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: 4-1BB ligand, 4-1BBL, TNFSF9
  • Entrez Gene ID: 21950
  • Molecular mass of antigen [kDa]: 34
  • Distribution of antigen: B cells, dendritic cells, fibroblasts, monocytes, macrophages, lymphocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, VioBright 515, Biotin, FITC
  • Selected references

    1. Goodwin, R. G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23(10): 2631-2641
    2. Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229(1): 192-215
    3. Ma, J. et al. (2013) The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal 6(295): ra87
Product options: 13
30 µg in 200 µL (1)
CHF  45.00
30 µg in 200 µL (1)
CHF  85.00
150 µg in 1 mL (1)
CHF  250.00
30 µg in 200 µL (1)
CHF  85.00
150 µg in 1 mL (1)
CHF  250.00
30 µg in 200 µL (1)
CHF  110.00
150 µg in 1 mL (1)
CHF  325.00
30 µg in 200 µL (1)
CHF  110.00
150 µg in 1 mL (1)
CHF  325.00
30 µg in 200 µL (1)
CHF  160.00
150 µg in 1 mL (1)
CHF  460.00
30 µg in 200 µL (1)
CHF  45.00
150 µg in 1 mL (1)
CHF  130.00

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