CD127 antibodies, human

CD127 antibodies, human

Clone: REA614 | Dilution: 1:50
Clone REA614 recognizes the CD127 antigen, which is the α-chain of the interleukin 7 (IL-7) receptor, a type I membrane glycoprotein. Signaling of IL-7 through the IL-7R requires both IL-7Rα and the common cytokine gamma chain (γc). CD127 can be identified on immature B cells through the early pre–B stage, on thymocytes, and on most mature T cells with transient down-regulation upon activation. On regulatory T cells CD127 is absent and its expression is inversely correlated with FoxP3 expression and suppressive function. CD127 is also used by thymic stromal derived lymphopoietin (TSLP) as part of a complex.
Additional information: Clone REA614 displays negligible binding to Fc receptors.

Alternative names

IL-7R, IL-7Rα, IL-17Ralpha, CDW127, ILRA

Technical specifications

  • Antigen: CD127
  • Clone: REA614
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL-7R, IL-7Rα, IL-17Ralpha, CDW127, ILRA
  • Entrez Gene ID: 3575
  • Molecular mass of antigen [kDa]: 50
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, VioBright 515
  • Selected references

    1. Fry, T. J. and Mackall, C. L. (2002) Interleukin-7: from bench to clinic. Blood 99: 3892-3904
    2. Seddiki, N. et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203: 1693-1700
    3. Liu, W. et al. (2006)
      CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4
      +
      T reg cells.
      J. Exp. Med. 203: 1701-1711
    4. Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129
    5. Cupedo, T. et al. (2005) Development and activation of regulatory T cells in the human fetus. Eur. J. Immunol. 35: 383-390
    6. Armitage, R. J. et al. (1991) Expression of receptors for interleukin 4 and interleukin 7 on human T cells. Adv. Exp. Med. Biol. 292: 121-130
Product options: 12
130-113-979

CD127-VioBright FITC, human

for 30
tests
(1)
CHF  130.00
130-113-417

CD127-VioBright FITC, human

for 100
tests
(1)
CHF  315.00
130-113-976

CD127-PE, human

for 30
tests
(1)
CHF  120.00
130-113-414

CD127-PE, human

for 100
tests
(1)
CHF  290.00
130-113-975

CD127-APC, human

for 30
tests
(1)
CHF  120.00
130-113-413

CD127-APC, human

for 100
tests
(1)
CHF  290.00
130-113-977

CD127-PE-Vio770, human

for 30
tests
(1)
CHF  130.00
130-113-415

CD127-PE-Vio770, human

for 100
tests
(1)
CHF  315.00
130-113-978

CD127-APC-Vio770, human

for 30
tests
(1)
CHF  130.00
130-113-416

CD127-APC-Vio770, human

for 100
tests
(1)
CHF  315.00
130-120-113

CD127-VioBright 515, human

for 30
tests
(1)
CHF  165.00
130-120-027

CD127-VioBright 515, human

for 100
tests
(1)
CHF  395.00

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