CD11b antibodies, mouse

CD11b antibodies, mouse

Clone: REA592 | Dilution: 1:10
Clone REA592 recognizes the mouse CD11b antigen (Mac-1 α; integrin αM chain), which is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. CD11b is expressed on monocytes, macrophages, and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5
+
B-1 cells, and subsets of dendritic cells. Clone REA592 recognizes also the non-human primate and human CD11b antigen.
Additional information: Clone REA592 displays negligible binding to Fc receptors.

Alternative names

integrin αM, Mac-1 α, Integrin alpha-M, CR3A

Technical specifications

  • Antigen: CD11b
  • Clone: REA592
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: integrin αM, Mac-1 α, Integrin alpha-M, CR3A
  • Entrez Gene ID: 3684, 16409
  • Molecular mass of antigen [kDa]: 126
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    , human
  • Distribution of antigen: monocytes, macrophages, microglia, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC-Vio770
  • Selected references

    1. Pahl, H. L. et al. (1992) Characterization of the myeloid-specific CD11b promoter. Blood 79(4): 865-870
    2. Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
    3. Liu, T. et al. (2014)
      Gr-1
      +
      CD11b
      +
      cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
      Sci. Rep. 4: 4833
Product options: 2
9 µg in 300 µL (1)
CHF  75.00
30 µg in 1 mL (1)
CHF  110.00