Anti-TNF-β antibodies, human

Anti-TNF-β antibodies, human

Clone: REA1169 | Dilution: 1:50
Clone REA1169 recognizes the human TNF-β antigen, a cytokine belonging to the tumor necrosis factors (TNF) family. TNF-β is also known as lymphotoxin-a and is produced by activated lymphocytes, for example CD4
+
and CD8
+
T cells and some B lymphoblastoid cell lines. TNF-β and TNF-α, which have similar biological activities and same receptors, are able to inhibit tumor growth. TNF-β induces the synthesis of GM-CSF, G-CSF, interleukin 1 (IL-1), collagenase, and is a mitogen for B-lymphocytes.
Additional information: Clone REA1169 displays negligible binding to Fc receptors.

Alternative names

TNF-beta, TNF-b, LT-alpha, LT-α

Technical specifications

  • Antigen: TNF-β
  • Clone: REA1169
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: TNF-beta, TNF-b, LT-alpha, LT-α
  • Entrez Gene ID: 4049
  • Molecular mass of antigen [kDa]: 19
  • Distribution of antigen: T cells, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Nedospasov, S. A. et al. (1985) Tandem arrangement of genes coding for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) in the human genome. Cold Spring Harb. Symp. Quant. Biol. 51(1): 611-624
    2. Nedwin, G. E. et al. (1985) Structure and chromosomal localization of the human lymphotoxin gene. J. Cell. Biochem. 29(3): 171-181
    3. Browning, J. L. et al. (1993) Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell 72(6): 847-856
Product options: 4
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00