Anti-PI-16 antibodies, human

Anti-PI-16 antibodies, human

Clone: REA699 | Dilution: 1:50
Clone REA699 recognizes the human peptidase inhibitor 16 (PI-16) antigen, also known as CRISP-9 or PSP94-binding protein. PI-16 belongs to the Activity cysteine-rich secretory protein (CRISP) family and is expressed in prostate, testis, ovary, and intestine. It is reported to be an independent prognostic marker for prostate cancer. Additionally, PI-16 is over-expressed by CD4
+
/CD25
+
Treg cells, so it identifies a novel distinct subset of functional memory Treg cells, that are able to migrate to sites of inflammation and regulate the pro-inflammatory response.
Additional information: Clone REA699 displays negligible binding to Fc receptors.

Alternative names

Peptidase inhibitor 16, CRISP-9, PSP94-binding protein

Technical specifications

  • Antigen: PI-16
  • Clone: REA699
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Peptidase inhibitor 16, CRISP-9, PSP94-binding protein
  • Entrez Gene ID: 221476
  • Molecular mass of antigen [kDa]: 47
  • Distribution of antigen: ovary, prostate, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Reeves, J. R. et al. (2005) Identification, purification and characterization of a novel human blood protein with binding affinity for prostate secretory protein of 94 amino acids. Biochem. J. 385(1): 105-114
    2. Nicholson, I. C. et al. (2012) PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20. Cell. Immunol. 275(1–2): 12-18
    3. Reeves, J. R. et al. (2006) Prognostic value of prostate secretory protein of 94 amino acids and its binding protein after radical prostatectomy. Clin. Cancer Res. 12(20): 6018-6022
Product options: 8
130-111-737

Anti-PI-16-VioBright FITC, human

for 30
tests
(1)
CHF  130.00
130-111-659

Anti-PI-16-VioBright FITC, human

for 100
tests
(1)
CHF  315.00
130-111-364

Anti-PI-16-PE, human

for 30
tests
(1)
CHF  120.00
130-111-176

Anti-PI-16-PE, human

for 100
tests
(1)
CHF  290.00
130-111-365

Anti-PI-16-APC, human

for 30
tests
(1)
CHF  120.00
130-111-177

Anti-PI-16-APC, human

for 100
tests
(1)
CHF  290.00
130-111-363

Anti-PI-16-Biotin, human

for 30
tests
(1)
CHF  100.00
130-111-175

Anti-PI-16-Biotin, human

for 100
tests
(1)
CHF  245.00

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