Anti-Mcl-1 pS159 antibodies, human and mouse

Anti-Mcl-1 pS159 antibodies, human and mouse

Clone: REA924 | Dilution: 1:50
Clone REA924 recognizes the human and mouse protein Mcl-1 phosphorylated at serine 159 (pS159). Myeloid cell leukemia-1 (Mcl-1), also known as BCL2L3, is a member of the Bcl-2 family of regulator proteins, which play an important role in the regulation of apoptosis. The two isoforms of Mcl-1 regulate cell survival and apoptosis by inhibiting apoptosis and promotion of apoptosis and death-inducing. Mcl-1 is primarily found in the outer membrane of mitochondria and mainly expressed in programmed myeloid cell differentiation.
Additional information: Clone REA924 displays negligible binding to Fc receptors.

Alternative names

MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1

Technical specifications

  • Antigen: Mcl-1 pS159
  • Clone: REA924
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MCL1BCL2L3, Bcl2-L-3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1
  • Entrez Gene ID: 4170, 17210
  • Molecular mass of antigen [kDa]: 37, 35
  • Distribution of antigen: myeloid cells, myeloid leukemia cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC
  • Selected references

    1. Kozopas, K. M. et al. (1993) MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2. Proc. Natl. Acad. Sci. U.S.A. 90(8): 3516-3520
    2. Chao, J. R. et al. (1998) mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response. Mol. Cell. Biol. 18(8): 4883-4898
    3. Bingle, C. D. et al. (2000) Exon skipping in Mcl-1 results in a bcl-2 homology domain 3 only gene product that promotes cell death. J. Biol. Chem. 275(29): 22136-22146
    4. Maurer, U. et al. (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol. Cell 21(6): 749-760
Product options: 6
for 30
tests
(1)
CHF  100.00
for 100
tests
(1)
CHF  245.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00

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