Anti-KIR2D antibodies, human

Anti-KIR2D antibodies, human

Clone: REA1042 | Dilution: 1:50
Clone REA1042 recognizes the killer immunoglobulin-like receptor (KIR) 2D subtype on human and non-human primate cells. It recognizes all KIRs bearing two extracellular Ig-like domains, and also both activating and inhibitory KIR isoforms (KIR2DS and KIR2DL, respectively). KIRs are expressed on CD56
dim
CD16
+
natural killer (NK) cells and a subset of CD8
+
T cells. KIRs contribute to the regulation of NK cell–mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either two or three Ig-like extracellular domains (KIR2D or KIR3D, respectively). According to the length of their cytoplasmic tail, KIRs can be subdivided in long-tailed inhibitory KIRs (KIR2DL or KIR3DL) and short-tailed activating KIRs (KIR2DS or KIR3DS).
Additional information: Clone REA1042 displays negligible binding to Fc receptors.

Alternative names

CD158A

Technical specifications

  • Antigen: KIR2D
  • Clone: REA1042
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD158A
  • Entrez Gene ID: 3806, 3808, 3809, 3810, 3802, 3803, 3804, 3805, 57292, 100132285
  • Molecular mass of antigen [kDa]: 31-39
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Selvakumar, A. et al. (1997) Polymorphism and domain variability of human killer cell inhibitory receptors. Immunol. Rev. 155: 183-196
    2. Djeu, J. et al. (2002) A view to a kill: signals triggering cytotoxicity. Clin. Cancer Res. 8: 636-640
    3. Hsu, K. et al. (2002) The killer cell immunoglobin-like (KIR) genomic region: gene-order, haplotypes and allelic polymorphism. Immunol. Rev. 190: 40-52
Product options: 21
for 30
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(1)
CHF  105.00
for 100
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CHF  250.00
for 30
tests
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CHF  125.00
for 100
tests
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CHF  295.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  295.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  305.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  305.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00
for 30
tests
(1)
CHF  165.00
for 100
tests
(1)
CHF  395.00
for 30
tests
(1)
CHF  105.00
for 100
tests
(1)
CHF  250.00

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