Anti-IL-1β antibodies, human

Anti-IL-1β antibodies, human

Clone: REA1172 | Dilution: 1:50
Clone REA1172 recognizes the human IL-1β protein, a proinflammatory cytokine which belongs to the interleukin 1 (IL-1) family. IL-1β is primarly produced by macrophages, but also by monocytes and dendritic cells. It is secreted as a proprotein, that is cleaved by cytosolic caspase 1 (interleukin 1 beta convertase/CASP1/ICE) to form mature IL-1β. It plays an essential role in inflammatory response, promotes cell differentiation, e.g. Tʜ17 differentiation of T cells, and is involved in other cellular activities, including apoptosis.
Additional information: Clone REA1172 displays negligible binding to Fc receptors.

Alternative names

IL-1beta, IL-1B, IL1B, IL1F2

Technical specifications

  • Antigen: IL-1β
  • Clone: REA1172
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: IL-1beta, IL-1B, IL1B, IL1F2
  • Entrez Gene ID: 3553
  • Molecular mass of antigen [kDa]: 17
  • Cross-reactivity: baboon
  • Distribution of antigen: dendritic cells, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Vio515
  • Selected references

    1. Van Damme, J. et al. (1985) Homogeneous interferon-inducing 22K factor is related to endogenous pyrogen and interleukin-1. Nature 314(6008): 266-268
    2. Zsebo, K .M. et al. (1988) Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow. Blood 71(4): 962-968
    3. Lukens, J. R. et al. (2014) Dietary modulation of the microbiome affects autoinflammatory disease. Nature 516(7530): 246-249
Product options: 6
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  125.00
for 100
tests
(1)
CHF  305.00

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