Anti-HLA Class I Bw4 antibodies, human

Anti-HLA Class I Bw4 antibodies, human

Clone: REA274 | Dilution: 1:11
Clone REA274 recognizes HLA Bw4, a class I human leukocyte antigen (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. Analysis of HIV-infected patients found the combination of the NK cell receptor KIR3DS1/L1 and a presumptive HLA Bw4 ligand to be correlated with slower progression to AIDS.
Additional information: Clone REA274 displays negligible binding to Fc receptors.

Alternative names

HLA-B, AS, SPDA1

Technical specifications

  • Antigen: HLA Class I Bw4
  • Clone: REA274
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-B, AS, SPDA1
  • Entrez Gene ID: 3106
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Carr, W. H. et al. (2005) KIR3DL1 polymorphisms that affect NK cell inhibition by HLA-Bw4 ligand. J. Immunol. 175(8): 5222-5229
    2. Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110(2): 163-169
    3. Martin, M. P. et al. (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat. Genet. 39(6): 733-740
    4. Garrido, C. et al. (2016) HIV latency-reversing agents have diverse effects on natural killer cell function. Front Immunol 7: 356
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for 100
tests
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CHF  315.00
for 30
tests
(1)
CHF  105.00
for 100
tests
(1)
CHF  250.00

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