Anti-HLA-B7, B27 antibodies, human

Anti-HLA-B7, B27 antibodies, human

Clone: REA176 | Dilution: 1:11
Clone REA176 recognizes HLA B7 and B27 class I human leukocyte antigens (HLA). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, of which one comprises the peptide binding groove. Antigens binding to class I molecules are 8–10 amino acids long and play an important role in recognition of the virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. HLA-B7 is a risk factor for cervical cancer, sarcoidosis, and early-onset spondylarthropathies. HLA-B27 is known for its strong association with inflammatory spondyloarthropathies. It has been also discovered as a protective factor against some severe viral infections.
Additional information: Clone REA176 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: HLA-B7, B27
  • Clone: REA176
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HLA-B, AS, SPDA1
  • Entrez Gene ID: 3106
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: nucleated cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin, APC
  • Selected references

    1. Akram, A. et al. (2014) HLA-B27, but not HLA-B7, immunodominance to influenza is ERAP dependent. J. Immunol. 192(12): 5520-5528
    2. Akram, A. et al. (2013) Co-expression of HLA-B7 and HLA-B27 alleles is associated with B7-restricted immunodominant responses following influenza infection. Eur. J. Immunol. 43(12): 3254-3267
    3. den Uyl, D. et al. (2004) Progression of HIV to AIDS: a protective role for HLA-B27? AIDS Rev. 6(2): 89-96
Product options: 2
for 30
CHF  105.00
for 100
CHF  257.00

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