Anti-GARP (LRRC32) antibodies, mouse

Anti-GARP (LRRC32) antibodies, mouse

Clone: REA139 | Dilution: 1:10
Clone REA139 recognizes murine GARP, a 80 KDa type I membrane glycoprotein which belongs to the family of leucine rich repeat proteins. Expression of GARP protein is found on megakaryocytes and platelets. Activated GARP has been found to be associated with latency associated peptide (LAP), the prodomain responsible for conferring latency to nonactive TGFβ. Thus, GARP as a latent TGFβ binding protein (LTBP) regulates the surface expression of TGFβ and serves as a carrier of LAP, at the cell surface, to immune response active sites, where TGFβ is eventually activated and released to exert further physiological functions such as differentiation of regulatory T cells.
Additional information: Clone REA139 displays negligible binding to Fc receptors.

Alternative Names

LRRC32, Garpin, Glycoprotein A repetitions predominant

Technical specifications

  • Antigen: GARP (LRRC32)
  • Clone: REA139
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: LRRC32, Garpin, Glycoprotein A repetitions predominant
  • Entrez Gene ID: 434215
  • Molecular mass of antigen [kDa]: 72
  • Distribution of antigen: T cells, megakaryocytes, platelets
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected References

    1. Tran, D. Q. et al. (2009)
      GARP (LRRC32) is essential for the surface expression of latent TGF-β on platelets and activated FOXP3
      +
      regulatory T cells.
      Proc. Natl. Acad. Sci. U.S.A. 106: 13445-13450
    2. Battaglia, M. et al. (2009) The Tregs' world according to GARP. Eur. J. Immunol. 39(12): 3296-3300
    3. Vermeersch, E. et al. (2017) The role of platelet and endothelial GARP in thrombosis and hemostasis. PLoS One 12(13): e0173329
    4. Wang, R. et al. (2008) Identification of a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 expression. PLoS One 3(7): e2705
    5. Ollendorff, V. et al. (1994) The GARP gene encodes a new member of the family of leucine-rich repeat-containing proteins. Cell Growth Differ. 5: 213-219
Product options: 6
130-102-921

Anti-GARP (LRRC32)-PE, mouse

9 µg in 300 µL (1)
CHF  42.00
130-102-182

Anti-GARP (LRRC32)-PE, mouse

30 µg in 1 mL (1)
CHF  63.00
130-102-919

Anti-GARP (LRRC32)-APC, mouse

9 µg in 300 µL (1)
CHF  65.00
130-102-174

Anti-GARP (LRRC32)-APC, mouse

30 µg in 1 mL (1)
CHF  98.00
130-102-026

Anti-GARP (LRRC32)-Biotin, mouse

9 µg in 300 µL (1)
CHF  28.00
130-101-847

Anti-GARP (LRRC32)-Biotin, mouse

30 µg in 1 mL (1)
CHF  42.00