Anti-ERK2 antibodies, human and mouse

Anti-ERK2 antibodies, human and mouse

Clone: REA186 | Dilution: 1:11
Clone REA186 recognizes ERK2, a 42 KDa serine/threonine protein kinase, which participates in the MAPK signal transduction pathway. It is involved in regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. ERK2 and the related kinase ERK1 are phosphorylated by kinases MEK1/2, leading to activation and nuclear translocation of ERKs, where they phosphorylate downstream targets, such as transcription factors including Ets, Elk, and c-Fos. ERK2 activation and mobilization is induced in reponse to several extracellular signals and engagement of receptors such as Tyr kinases (RTKs), G protein–coupled receptors (GPCRs), ion channels, and others. The ERK1/2 are dual specificity kinases and phosphorylate Ser or Thr residues neighbor to proline residue.
Additional Information: Clone REA186 displays negligible binding to Fc receptors.

Alternative names

MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2

Technical specifications

  • Antigen: ERK2
  • Clone: REA186
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: MAPK1, ERK, ERK-2, ERT1, MAPK2, P42MAPK, p38, PRKM1, PRKM2
  • Entrez Gene ID: 5594
  • Molecular mass of antigen [kDa]: 41
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770
  • Selected references

    1. Gonzalez-Perez, G. and Lamousé-Smith, E. S. (2017)
      Gastrointestinal microbiome dysbiosis in infant mice alters peripheral CD8
      +
      T cell receptor signaling.
      Front Immunol 8(8): 265
    2. Roskoski, R. et al. (2012) ERK1/2 MAP kinases: structure, function, and regulation. Pharmacol. Res. 66(2): 105-143
    3. Davis, R. J. et al. (1995) Transcriptional regulation by MAP kinases. Mol. Reprod. Dev. 42(4): 459-467
    4. Lloyd, A. C. (2006) Distinct functions for ERKs? J. Biol. 5(5): 13
Product options: 6
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  130.00
for 100
tests
(1)
CHF  315.00

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