Anti-Dectin-2 antibodies, mouse

Anti-Dectin-2 antibodies, mouse

Clone: REA1001 | Dilution: 1:50
Clone REA1001 recognizes the mouse dendritic cell–associated C-type lectin 2 (dectin-2) antigen. Dectin-2 is a type II membrane protein and contains a single carbohydrate recognition domain. Like other C-type lectins, mouse dectin-2 has conserved motifs for the Ca
2+
-dependent recognition of mannose. Dectin-2 is located in the natural killer gene complex of chromosome 6. Genomic analyses show that beside a full length dectin-2 transcript two truncated isoforms are produced by alternative splicing, encoding transmembrane proteins of 168–209 amino acids. The expression of dectin-2 on mouse monocytes and macrophages can be induced by zymosan and thioglycollate. Dectin-2 plays a physiological role in antigen presentation and antigen targeting via dectin-2 can induce a CD8
+
T cell response.
Additional information: Clone REA1001 displays negligible binding to Fc receptors.

Alternative names

CLEC4N, Clec6a, Clecsf10, Nkcl

Technical specifications

  • Antigen: Dectin-2
  • Clone: REA1001
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CLEC4N, Clec6a, Clecsf10, Nkcl
  • Entrez Gene ID: 56620
  • Molecular mass of antigen [kDa]: 24
  • Distribution of antigen: macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Fernandes, M. J. et al. (1999) Characterization of a novel receptor that maps near the natural killer gene complex: demonstration of carbohydrate binding and expression in hematopoietic cells. Cancer Res. 59: 2709-2717
    2. Ariizumi, K. et al. (2000) Cloning of a second dendritic cell-associated C-type lectin (dectin-2) and its alternatively spliced isoforms. J. Biol. Chem. 275: 11957-11963
    3. Taylor, P. R. et al. (2005)
      Dectin-2 is predominantly myeloid restricted and exhibits unique activation-dependent expression on maturing inflammatory monocytes elicited
      in vivo
      .
      Eur. J. Immunol. 35: 2163-2174
    4. Carter, R. W. et al. (2006)
      Induction of CD8
      +
      T cell responses through targeting of antigen to Dectin-2.
      Cell. Immunol. 239: 87-91
Product options: 2
130-116-910

Anti-Dectin-2-PE, mouse

30 µg in 200 µL (1)
CHF  85.00
130-116-911

Anti-Dectin-2-APC, mouse

30 µg in 200 µL (1)
CHF  85.00