Anti-c-Cbl pY700 antibodies, human and mouse

Anti-c-Cbl pY700 antibodies, human and mouse

Clone: REA362 | Dilution: 1:11
Clone REA362 recognizes the human and mouse c-Cbl antigen phosphorylated at tyrosine 700 (pY700). The multifunctional adaptor Cbl acts as a negative regulator of intracellular signaling induced by engagement of cell-surface receptors. The RING finger domain of Cbl has E3 ubiquitin ligase activity that catalyses ubiquitilation and targeting of critical signaling molecules to lysosomal or proteosomal degradation. Moreover, Cbl regulates endocytosis of receptor tyrosine kinase and activity of other signaling proteins through a proteolysis-independent mechanism. c-Cbl unlike the other Cbl proteins contains only a short proline-rich region and no C-terminal leucine zipper-like region. The c-Cbl adapter protein is expressed in the cytoplasm in all tissues, with especially high levels of expression in hematopoietic cells.
Additional information: Clone REA362 displays negligible binding to Fc receptors.

Alternative names

CBL, CBL2, FRA11B, NSLL, RNF55

Technical specifications

  • Antigen: c-Cbl pY700
  • Clone: REA362
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CBL, CBL2, FRA11B, NSLL, RNF55
  • Entrez Gene ID: 867
  • Molecular mass of antigen [kDa]: 100
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Brembilla, N. C. et al. (2008) c-Cbl expression levels regulate the functional responses of human central and effector memory CD4 T cells. Blood 112(3): 652-660
    2. Joazeiro, C. A. P. et al. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309
    3. Rao, N. et al. (2002) The Cbl family of ubiquitin ligases: critical negative regulators of tyrosine kinase signaling in the immune system. J. Leukoc. Biol. 71: 753-763
Product options: 4
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00
for 30
tests
(1)
CHF  120.00
for 100
tests
(1)
CHF  290.00

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