Anti-Bcl-6 antibodies, human and mouse

Anti-Bcl-6 antibodies, human and mouse

Clone: REA373
Clone REA373 recognizes the human and mouse Bcl-6 antigen, a member of the BTB-zinc finger family of proteins. Bcl-6 is a transcriptional repressor, expressed in germinal center T and B cells and in primary immature dendritic cells. It plays critical functions in various cell types within the adaptive and innate compartments of the immune system. Bcl-6 is highly up-regulated in B cells after T cell–dependent antigenic challenge, and is required for formation of germinal centers within which B cells undergo immunoglobulin affinity maturation. It also plays an important role in macrophages, where it mediates a dampening effect on inflammatory signaling through repression of chemokine expression and NF-κB target genes.
Additional information: Clone REA373 displays negligible binding to Fc receptors.

Alternative names


Technical specifications

  • Antigen: Bcl-6
  • Clone: REA373
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: BCL6, BCL5, BCL6A, LAZ3, ZBTB27, ZNF51
  • Entrez Gene ID: 604, 12053
  • Molecular mass of antigen [kDa]: 79
  • Distribution of antigen: T cells, B cells
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
Product options: 1
100 µg in 100 µL
CHF  205.00