PepTivator Influenza A (H1N1) MP1, human

PepTivator Influenza A (H1N1) MP1, human

Influenza A (H1N1) MP1 is a pool of lyophilized peptides, consisting mainly of 15-mer sequences with 11 amino acids overlap, covering the complete sequence of the human influenza A virus MP1 protein (UniProt ID: C3W5X4).
in vitro
stimulation of antigen-specific T cells with PepTivator Peptide Pools causes the secretion of effector cytokines and the up-regulation of activation markers, which then allow the detection and isolation of antigen-specific T cells.

Background information

The influenza A virus, subtype H1N1, was the most common cause of human influenza in 2009. Some strains of H1N1 are endemic in humans, pigs, and birds.
The matrix protein 1 (MP1) is thought to play a critical role in virus replication, virus entry, as well as uncoating and budding of the virus particle. Moreover, MP1 is a major target for virus-specific T cell immunity.

Downstream applications

PepTivator Influenza A (H1N1) MP1 - research grade has been specifically developed for efficient
in vitro
stimulation of influenza A MP1–specific T cells. Peptides of 15 amino acids in length and 11 amino acids overlap represent an optimized solution for stimulating both CD4
and CD8
T cells in various applications, including:
  • Detection and analysis of influenza A MP1–specific effector/memory T cells in PBMCs by MACS Cytokine Secretion Assays, intracellular cytokine staining, or other technologies.
  • Isolation of viable influenza A MP1–specific CD4+ T cells with the CD154 MicroBead Kit, or of CD4+ and CD8+ T cells using the CD137 MicroBead Kit or MACS Cytokine Secretion Assay – Cell Enrichment and Detection Kits. Subsequently, cells can be expanded for generation of T cell lines.
  • Generation of influenza A MP1–specific effector/memory T cells from naive T cell populations.
  • Pulsing of antigen-presenting cells.
Product options: 1
stimulation of
CHF  196.00

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