Mouse IL-7

Mouse IL-7

IL-7 stands for interleukin 7. Mouse IL-7 is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays.

Applications

Mouse IL-7 may be used for a variety of applications, including:
  • In vitro T cell expansion, for example, of naive T cells.
  • In vitro differentiation of T cells, for example, of iNKT cells.
  • Investigation of IL-7 mediated signaling pathways.

Background information

Interleukin 7 (IL-7) is a member of the type I cytokine family. The primary sources of IL-7 are non-hematopoietic stromal cells in bone marrow, thymus, and lymphoid organs and tissues. It is a pleiotropic cytokine with central roles in modulating T cell and B cell development and peripheral T cell homeostasis. IL-7 can act both as a T cell growth factor as well as a critical anti-apoptotic survival factor. IL-7 is related to IL-2 and signals through a heterodimeric receptor composed of the common cytokine signaling γ-chain and IL-7 receptor α-chain.

Quality description

Research-grade
cytokines are suitable for a wide variety of cell culture applications. They are sterile-filtered prior to lyophilization. Generally, endotoxin levels are <0.1 ng/μg (<1 EU/μg), and purities are >95%. The biological activity is tested in appropriate bioassays.

Biological activity

  • Proliferation of mouse 2E8 cells
  • research grade: ≥ 5×
    10
    6
    U/mg
  • Selected references

    1. Engelmann S. et al. (2013) T cell-independent modulation of experimental autoimmune encephalomyelitis in ADAP-deficient mice. J. Immunol. 191(10): 4950-4959
    2. Laurenti, E. et al. (2015) CDK6 levels regulate quiescence exit in human hematopoietic stem cells. Cell Stem Cell 16(3): 302-313
    3. Velardi, E. et al. (2014) Sex steroid blockade enhances thymopoiesis by modulating Notch signaling. J. Exp. Med. 211(12): 2341-2349
    4. Dussiau C. et al. (2015) Targeting IRAK1 in T-cell acute lymphoblastic leukemia. Oncotarget 6: 18956-18965
    5. Ishihara, K. et al. (1991) Stromal-cell and cytokine-dependent lymphocyte clones which span the pre-B-to B-cell transition. Dev. Immunol. 1: 149-161
  • Certificates

    Please follow this
    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 4
E. coli
2 µg
CHF  75.00
E. coli
10 µg
CHF  260.00
E. coli
100 µg
CHF  1'150.00
E. coli
1000 µg
CHF  5'795.00