Human PDGF-BB IS

Human PDGF-BB IS

PDGF-BB IS stands for platelet derived growth factor BB "Improved Sequence". Human PDGF-BB IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. Human PDGF-BB IS possesses the same properties as naturally occurring PDFG-BB.

Applications

Human PDGF-BB IS can be used for a variety of applications, including:
  • MSC culture and investigation of MSC development.
  • Studies of angiogenesis.

Background information

Platelet-derived growth factor-BB (PDGF-BB) is a dimeric protein composed by two identical B subunits, it belongs to the PDGF family together with the two receptors PDGFRα and PDGFRβ. PDGF-BB binds PDGFRβ with the highest affinity. It regulates mesenchymal cell growth, morphogenesis, and migration, especially during angiogenesis and glial cell proliferation. A dysregulation of PDGF was shown in diseases such as diabetes, and in deficit of bone formation and reparation. Human PDGF-BB IS is an engineered PDGF-BB variant retaining the same biological properties as natural accurring PDGF-BB.

Biological activity

  • Proliferation of 3T3 cells (NIBSC 94/728)
  • premium grade: ≥ 1×
    10
    6
    IU/mg
  • research grade: ≥ 5×
    10
    5
    IU/mg
  • Certificates

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    link
    to search for Certificates of Analysis (CoA) by lot number.
Product options: 6
Pichia pastoris
10 µg
-
Pichia pastoris
25 µg
CHF  285.00
Pichia pastoris
10 µg
-
Pichia pastoris
25 µg
-
Pichia pastoris
100 µg
-
Pichia pastoris
1000 µg
CHF  3'035.00