Clone:
REA666
Type of antibody:
Primary antibodies, Recombinant antibodies
Isotype:
recombinant human IgG1
Applications:
ICFC
Alternative names:
Interleukin-17F

Specifications for IL-17F Antibody, anti-mouse, REAfinity™

Overview

Clone REA666 recognizes the mouse interleukin 17F (IL-17F) antigen, a cytokine which is expressed by a subset of activated T cells in the lamina propria. IL-17F belongs to the IL-17 gene family, which consists of six members (IL-17A, IL-17B, IL-17C, IL-17D, IL-17E, and IL-17F). All members have a similar protein structure, with four highly conserved cysteine residues critical to their 3-dimensional shape. The isoforms of IL-17F 1 and 2 (ML-1) have the highest homology to IL-17A. It has been reported, that IL-17–producing T lymphocytes comprise a distinct lineage of proinflammatory T helper cells, termed Tʜ17 cells, that are major contributors to autoimmune disease. IL-17F plays a role in the induction of neutrophilia in the lungs and in the exacerbation of Ag-induced pulmonary inflammation.
Additional information: Clone REA666 displays negligible binding to Fc receptors.

Alternative names

Interleukin-17F

Detailed product information

Technical specifications

CloneREA666
Clonalitymonoclonal
Isotyperecombinant human IgG1
Isotype controlREA Control Antibody, human IgG1
Hostcell line
Type of antibodyPrimary antibodies, Recombinant antibodies
Speciesmouse
AntigenIL-17F
Alternative names of antigenInterleukin-17F
Molecular mass of antigen [kDa]15
Distribution of antigenT cells
Entrez Gene ID257630
RRIDAB_2652365, AB_2652366, AB_2652367, AB_2652364

References for IL-17F Antibody, anti-mouse, REAfinity™

Publications

  1. Ivanov, I. I. et al. (2006)
    The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17
    +
    T helper cells.
    Cell 126: 1121-1133
  2. Suzuki, S. et al. (2007) Expression of interleukin-17F in a mouse model of allergic asthma. Int. Arch. Allergy Immunol. 143: 89-94
  3. Oda, N. et al. (2005) Interleukin-17F induces pulmonary neutrophilia and amplifies antigen-induced allergic response. Am J Respir Crit Care Med. 171(1): 12-18

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