Clone:
REAL1142
Type of antibody:
Releasable fluorochromes, Primary antibodies, Recombinant antibodies
Applications:
MICS, IHC, IF
Alternative names:
NCAM1, NCAM-1, MSK39, NCAM, Leu-19, NKH-1

Specifications for CD56 (NCAM1) Antibody, anti-human, REAdye_lease™

Overview

Clone REAL1142 is an antibody fragment derived from the full CD56 (NCAM1) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity.
Clone REA1142 recognizes the human CD56 (NCAM1) antigen, a glycoprotein of the Ig-superfamily, also known as neural cell adhesion molecule (NCAM), which plays a role in cell-to-cell adhesion and cell-matrix interactions during embryonic development. Expression is found in blood on all resting and activated NK cells and on a minor subset of CD3
+
T cells. It is also expressed in brain (cerebellum and cortex) and at neuromuscular junctions. CD56 (NCAM1) expression is seen in solid tumors and hematological malignancies including multiple myeloma and leukemia.
For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675).

Alternative names

NCAM1, NCAM-1, MSK39, NCAM, Leu-19, NKH-1

Detailed product information

Technical specifications

CloneREAL1142
Clonalitymonoclonal
Isotype controlControl Antibody
Hostcell line
Type of antibodyReleasable fluorochromes, Primary antibodies, Recombinant antibodies
Specieshuman
AntigenCD56 (NCAM1)
Alternative names of antigenNCAM1, NCAM-1, MSK39, NCAM, Leu-19, NKH-1
Distribution of antigenNK cells, tumor cells, myeloid leukemia cells, leukemia cells, brain

References for CD56 (NCAM1) Antibody, anti-human, REAdye_lease™

Publications

  1. Camp, B. V. et al. (1990) Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19). Blood 76: 377-382
  2. Michalides, R. et al. (1994) NCAM and lung cancer. Int. J. Cancer 8: 34-37
  3. Carter, D. L. et al. (1999)
    CD56 identifies monocytes and not natural killer cells in
    Rhesus macaques
    .
    Cytometry 37: 41-50
  4. Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice. PLoS One 6(3): e17454

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