Clone:
7E.17G9
Type of antibody:
Primary antibodies
Isotype:
rat IgG2bκ
Applications:
FC
Alternative names:
ICOS, AILIM, CCLP, CRP-1, H4, Ly115

Specifications for CD278 (ICOS) Antibody, anti-mouse

Overview

Clone 7E.17G9 reacts with CD278, the inducible co-stimulatory molecule (ICOS), a 47–57 kDa homodimeric glycoprotein of the CD28 family. Directly
ex vivo
, CD278 is expressed only by a small subset of T cells, including follicular B helper T cells (TFH) and regulatory T cells. However, CD278 is strongly up-regulated on the surface following T cell activation. Upon binding to its ligand (ICOSL), CD278 initiates a multitude of events, which modulate many different aspects of T cell–mediated immune responses. Besides regulating differentiation and activation of effector as well as regulatory CD4
+
T cells, ICOS also plays a role in germinal center formation and isotype switching.

Alternative names

ICOS, AILIM, CCLP, CRP-1, H4, Ly115

Detailed product information

Technical specifications

Clone7E.17G9
Clonalitymonoclonal
Isotyperat IgG2bκ
Isotype controlIsotype Control Antibody, rat IgG2b
Hostrat
Type of antibodyPrimary antibodies
Speciesmouse
AntigenCD278 (ICOS)
Alternative names of antigenICOS, AILIM, CCLP, CRP-1, H4, Ly115
Molecular mass of antigen [kDa]20
Distribution of antigenB cells, T cells, thymocytes
Entrez Gene ID54167
RRIDAB_2660675, AB_2660676, AB_2660677, AB_2660679, AB_2660680, AB_2660681, AB_2660682, AB_2660683, AB_2660684, AB_2660685, AB_2660686, AB_2660687, AB_2857604

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