Different proliferation- and cell cycle-related antigens have been described, allowing for the evaluation of cell kinetic parameters by detecting the expression of these antigens.
Cyclins are a family of proteins that control the progression of cells through the cell cycle by activating cyclin-dependent kinase (CDK) enzymes. The most important cyclins involved in cell cycle processes are listed below.
|Cyclin A||Control of S phase in complex with Cdk1 or Cdk2||Cdk1 or Cdk2|
|Cyclin B||Control of G2/M phase in complex with Cdk1||Cdk1|
|Cyclin D||Control of G1 phase in complex with Cdk4 or Cdk6; Regulation of Rb/E2F transcription||Cdk4 or Cdk6|
|Cyclin E||Control of G1-S phase in complex with Cdk2; Regulation of Rb/E2F transcription||Cdk2|
|Cyclin H||Cdk-activating kinase and RNAPII transcription in complex with Cdk7||Cdk7|