Therapeutic plasma exchange (TPE) facilitates the unselective removal of pathogenic substances from the patient’s plasma. Such pathogens include paraproteins, autoantibodies, immune complexes, protein-bound toxins, and mediators of inflammation.
During TPE the plasma is separated from cellular blood components by the LIFE 21
apheresis unit. The plasma is discarded and replaced by substitution solutions. Usually, 1–1.5 times the patient’s plasma volume is exchanged in a session.