CD64 antibodies, human

CD64 antibodies, human

Clone: REA978 | Dilution: 1:50
Clone REA978 recognizes the human CD64 antigen, a high affinity Fc receptor for IgG, also known as FcγRI. CD64 contains three Ig-like domains in its extracellular domain and binds both monomeric and aggregated IgG and contributes to antibody-dependent cellular cytotoxicity (ADCC), phagocytosis, and the clearance of immune complexes. It is constitutively expressed on macrophages, monocytes, and eosinophils and can be up-regulated on neutrophils during infection or after stimulation with IFN-γ and colony-stimulating factors G-CSF and GM-CSF.
Additional information: Clone REA978 displays negligible binding to Fc receptors.

Alternative names

FCGR1A, CD64A, FcR I, IGFR1, FcγRI

Technical specifications

  • Antigen: CD64
  • Clone: REA978
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FCGR1A, CD64A, FcR I, IGFR1, FcγRI
  • Entrez Gene ID: 2209
  • Molecular mass of antigen [kDa]: 41
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    , baboon, capuchin monkey,
    squirrel monkey (
    Saimiri sciureus
    )
  • Distribution of antigen: granulocytes, macrophages, monocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Shen, L. et al. (1987) Polymorphonuclear leukocyte function triggered through the high affinity Fc receptor for monomeric IgG. J. Immunol. 139(2): 534-538
    2. Buckle, A. M. and Hogg, N. (1989) The effect of IFN-gamma and colony-stimulating factors on the expression of neutrophil cell membrane receptors. J. Immunol. 143(7): 2295-2301
    3. Herra, C. et al. (1996) Increased expression of Fc gamma receptors on neutrophils and monocytes may reflect ongoing bacterial infection. J. Med. Microbiol. 44(2): 135-140
Product options: 20
130-116-298

CD64-FITC, human

for 30
tests
(1)
-
130-116-195

CD64-FITC, human

for 100
tests
(1)
-
130-116-299

CD64-PE, human

for 30
tests
(1)
-
130-116-196

CD64-PE, human

for 100
tests
(1)
-
130-116-300

CD64-APC, human

for 30
tests
(1)
-
130-116-197

CD64-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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