CD57 antibodies, human

CD57 antibodies, human

Clone: TB03 | Dilution: 1:50
Clone TB03 specifically recognizes human CD57. CD57, also known as HNK-1 or Leu-7, is an antigenic oligosaccharide moiety detected on extracellular proteins of certain cell types. In blood, CD57 is found on 15–20% of mononuclear cells, including subsets of natural killer (NK) and T cells, though not on erythrocytes, monocytes, granulocytes, or platelets. Also, CD57 expression can be found on a variety of neural cell types.
CD57 has been shown to be expressed on late stage effector CD8
+
T cells. The frequency of CD57
+
T lymphocytes is raised in a variety of diseases. CD57 expression is also increased on chronically activated CD8
+
T cells in persistent viral infections, such as HIV.

Alternative names

B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1

Technical specifications

  • Antigen: CD57
  • Clone: TB03
  • Isotype: mouse IgMκ
  • Isotype control: Mouse IgM – isotype control antibodies
  • Alternative names of antigen: B3GAT1, GLCATP, GLCUATP, HNK-1, Leu-7, NK-1
  • Distribution of antigen: B cells, brain, CNS cells, NK cells, ES and iPS cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, APC-Vio770, FITC, PE-Vio615, VioBlue
  • Selected references

    1. Palmer, B. E. et al. (2005)
      Functional and phenotypic characterization of CD57
      +
      CD4
      +
      T cells and their association with HIV-1-induced T cell dysfunction.
      J. Immunol. 175: 8415-8423
    2. Brenchley, J. M. et al. (2003)
      Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8
      +
      T cells.
      Blood 101: 2711-2720
    3. Mechtersheimer, G. et al. (1991) Expression of the natural killer cell-associated antigens CD56 and CD57 in human neural and striated muscle cells and in their tumors. Cancer Res. 51: 1300-1307
    4. Dupuy d'Angeac, A. et al. (1993)
      Increased percentage of CD3
      +
      , CD57
      +
      lymphocytes in patients with rheumatoid arthritis. Correlation with duration of disease.
      Arthritis Rheum. 36: 608-612
    5. Ong, E. et al. (2002)
      Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 β1,6-
      N
      -acetylglucosaminyltransferase and the muscle-specific domain in NCAM.
      J. Biol. Chem. 277: 18182-18190
Product options: 10
130-118-665

CD57-APC, human

for 30
tests
(1)
-
130-118-537

CD57-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
130-122-979

CD57-FITC, human

for 30
tests
(1)
-
130-122-935

CD57-FITC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

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