CD43 antibodies, rat

CD43 antibodies, rat

Clone: REA503 | Dilution: 1:10
Clone REA503 recognizes the rat CD43 cell surface antigen, also known as leukosialin or sialophorin, which is a 371 amino acid heavily glycosylated single-pass type 1 transmebrane glycoprotein.
CD43 is expressed by most hematopoietic cells including peripheral T cells, NK cells, granulocytes, monocytes, thymocytes, platelets, plasma cells, activated B cells, and hemotopoietic progenitor cells. Leukosialin is involved in the costimulation of cell activation and survival as well as in cell-cell adhesion and anti-adhesion, and plays a role in inducement the apoptosis of T cells and hematopoietic progenitor cells.
Additional information: Clone REA503 displays negligible binding to Fc receptors.

Alternative names

Spn, Lsn, Lsn1, gpL115, Ly-48

Technical specifications

  • Antigen: CD43
  • Clone: REA503
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Spn, Lsn, Lsn1, gpL115, Ly-48
  • Entrez Gene ID: 24796
  • Molecular mass of antigen [kDa]: 38
  • Distribution of antigen: T cells, NK cells, granulocytes, monocytes, thymocytes, platelets, plasma cells, B cells, hematopoietic cells, hemotopoietic progenitor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Barclay. A. N. (1981) The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues. Immunology 42(4): 593-600
    2. Killeen, N. et al. (1987) The sequence of rat leukosialin (W3/13 antigen) reveals a molecule with O-linked glycosylation of one third of its extracellular amino acids. EMBO J. 6(13): 4029-4034
    3. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166(6): 3637-3640
Product options: 14
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
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130-107-719

CD43-PE, rat

9 µg in 300 µL (1)
-
130-107-684

CD43-PE, rat

30 µg in 1 mL (1)
-
130-107-720

CD43-APC, rat

9 µg in 300 µL (1)
-
130-107-685

CD43-APC, rat

30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-
9 µg in 300 µL (1)
-
30 µg in 1 mL (1)
-
130-107-718

CD43-Biotin, rat

9 µg in 300 µL (1)
-
130-107-683

CD43-Biotin, rat

30 µg in 1 mL (1)
-

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