CD4 antibodies, mouse

CD4 antibodies, mouse

Clone: REA1211 | Dilution: 1:50
Clone REA1211 recognizes the mouse CD4 antigen, a cell surface glycoprotein, which is a member of the immunoglobulin superfamily. It is also known as L3T4 or Leu-3. In mice, CD4 is expressed on T helper cells, regulatory T cells, and at lower levels on subpopulations of NKT cells and dendritic cells. It is furthermore detected on most thymocytes (CD4
+
CD8
+
and CD4
+
CD8
thymocytes). CD4 interacts with MHC class II molecules on the surface of antigen presenting cells. It increases the avidity of the interaction between T cells and antigen-presenting or target cells.
Additional information: Clone REA1211 displays negligible binding to Fc receptors.

Alternative names

L3T4, T4, Leu-3, Ly-4

Technical specifications

  • Antigen: CD4
  • Clone: REA1211
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: L3T4, T4, Leu-3, Ly-4
  • Entrez Gene ID: 12504
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: T cells, dendritic cells, NKT cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin, PE
  • Selected references

    1. Tourvieille, B. et al. (1986) Isolation and sequence of L3T4 complementary DNA clones: expression in T cells and brain. Science 234(4776): 610-614
    2. Bierer, B. E. et al. (1989) The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu. Rev. Immunol. 7: 579-599
    3. Parnes, J. R. et al. (1987) L3T4 and the immunoglobulin gene superfamily: new relationships between the immune system and the nervous system. Immunol. Rev. 100: 109-127
Product options: 10
130-123-206

CD4-PE, mouse

30 µg in 200 µL (1)
-
130-123-207

CD4-APC, mouse

30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
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30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
-
30 µg in 200 µL (1)
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