CD276 antibodies, human

CD276 antibodies, human

Clone: REA1094 | Dilution: 1:50
Clone REA1094 recognizes the human CD276 antigen, a type I transmembrane protein expressed at low levels in human liver, lung, bladder, testis, prostate, breast, placenta, lymphoid organs, and many human cancers. Surface expression can be induced on T cells, natural killer cells, and macrophages as well as on dendritic cells (DC) by interferon γ (IFN-γ) and on monocytes by granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4). CD276 has been shown to function as costimulatory molecule for T cell activation by inducing T cell proliferation and IFN-γ production.
Additional information: Clone REA1094 displays negligible binding to Fc receptors.

Alternative names

4Ig-B7-H3, B7-H3, B7RP-2

Technical specifications

  • Antigen: CD276
  • Clone: REA1094
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 4Ig-B7-H3, B7-H3, B7RP-2
  • Entrez Gene ID: 80381
  • Molecular mass of antigen [kDa]: 54
  • Distribution of antigen: B cells, dendritic cells, epithelial cells, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Chapoval, A. I. et al. (2001) B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2(3): 269-274
    2. Castriconi, R. et al. (2004) Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis. Proc. Natl. Acad. Sci. U.S.A. 101(34): 12640-12645
    3. Chen, Y. W. et al. (2008) The immunoregulatory protein human B7H3 is a tumor-associated antigen that regulates tumor cell migration and invasion. Curr. Cancer Drug Targets 8(5): 404-413
Product options: 16
for 30
tests
(1)
-
for 100
tests
(1)
-
130-118-698

CD276-PE, human

for 30
tests
(1)
-
130-118-570

CD276-PE, human

for 100
tests
(1)
-
130-118-699

CD276-APC, human

for 30
tests
(1)
-
130-118-571

CD276-APC, human

for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-
for 30
tests
(1)
-
for 100
tests
(1)
-

Related products

3 products available